Magnetic nanomaterials and nanomedicine is an emerging research area which integrates nanotechnology with chemistry, biology, and medicine.

Our research focus on:

1. Design and synthesis of magnetic nanomaterials with excellent magnetic performance.

2. Magnetic nanomaterials mediated manipulation of molecular interaction, cell's function and fate, as well as therapy of major human diseases.

The research group can control the synthesis of iron oxide and ferrite nanoparticles with different sizes and shapes,and has done some original work in the regulation of size and shape:

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  Ultra small magnetic nanoparticles 2nm

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  Superparamagnetic nanoparticles 11nm

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  Superparamagnetic nanoparticles 20nm

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  Vortex magnetic nanoring 52nm

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  Vortex magnetic nanoring 138nm

The as-synthesized nanoparticles have good crystallinity and high monodispersity

After surface modification,the nanoparticles have good dispersion and high stability.

Using the thermal decomposition character of Fe-eruciate complex, we have developed a general dynamic simultaneous thermal decomposition (DSTD) strategy for controllable synthesis of monodisperse ultrasmall metal ferrite nanoparticles with sizes smaller than 4 nm. Ultrasmall metal ferrite nanoparticles can be used as high-performance T1 magnetic resonance imaging contrast agent.

Related Publications：
Zhang H, Li L, Liu X L, et al. Ultrasmall Ferrite Nanoparticles Synthesized via Dynamic Simultaneous Thermal Decomposition for High-Performance and Multifunctional T1 Magnetic Resonance Imaging Contrast Agent [J]. ACS nano, 2017, 11(4): 3614-3631.

2.Using the magnetic properties of the magnetization circumferential to the ring without dipole-dipole interactions, we have developed a stable magnetic colloidal system with size controllable ferrimagnetic vortex-domain iron oxide nanorings (FVIOs). Compared with the traditional superparamagnetic iron oxide nanoparticles, the FVIOs have a much higher saturation magnetization, higher magnetic resonance T2 contrast effect, rapider magnetic response and higher hyperthermia transfer efficiency.

Related Publications：
Fan H M, Yi J B, Yang Y, et al. Single-crystalline MFe2O4 nanotubes/nanorings synthesized by thermal transformation process for biological applications [J]. Acs Nano, 2009, 3(9): 2798-2808.
Fan H M, Olivo M, Shuter B, et al. Quantum dot capped magnetite nanorings as high performance nanoprobe for multiphoton fluorescence and magnetic resonance imaging[J]. Journal of the American Chemical Society, 2010, 132(42): 14803-14811.
Liu X L, Yang Y, Ng C T, et al. Magnetic vortex nanorings: a new class of hyperthermia agent for highly efficient in vivo regression of tumors[J]. Advanced Materials, 2015, 27(11): 1939-1944.